In the perpetual competition for survival, both humans and bacteria are in a constant state of evolution to better suit their changing environments. Tuberculosis, a disease with roots stretching back to ancient times, has been no stranger to this evolutionary dance. Thanks to scientific and medical advancements, anti-tuberculosis drugs have greatly reduced the disease’s spread and lethality. Yet, Mycobacterium tuberculosis is developing resistance to these traditional drugs at an alarming rate, underscoring the pressing need for innovative treatment methods. Macao Polytechnic University spearheaded the launch of the Centre for Artificial Intelligence Driven Drug Discovery (AIDD) in 2022. This centre is at the forefront of medical research, using artificial intelligence (AI) technology to design new drugs. Working with partners from academia and industry, the AIDD team is on a mission to find new substances that can fight tuberculosis through AI driven drug discovery, hoping to create better treatments for tuberculosis sooner.