Grant winners

THE LEVERHULME TRUST

International Networks

Basic sciences

• Award winner: Louise Harra

• Institution: University College London

• Value: £124,677

Probing the Sun: inside and out

• Award winner: Kevin Flynn

• Institution: Swansea University

• Value: £98,160

Placing marine mixotrophs in context-modelling mixotrophy in a changing world

Economics, business studies, industrial relations

• Award winner: Kevin Gray

• Institution: University of Sussex

• Value: £79,947

Emerging powers of the global South

Humanities

• Award winner: Jo Gill

• Institution: University of Exeter

• Value: £68,836

Suburban cultures network

Law, politics, international relations

• Award winner: Douglas Guilfoyle

• Institution: University College London

• Value: £16,072

The modern laws of high seas piracy project

Biotechnology and Biological Sciences Research Council

• Award winner: Matthew Piper

• Institution: University College London

• Value: about £538,000

Investigating the mechanisms by which amino acid balance and reduced TOR signalling improve healthy lifespans

• Award winner: Alison Smith

• Institution: John Innes Centre

• Value: about £568,000

Cytosolic invertases and the control of plant growth

• Award winner: Jason Micklefield

• Institution: University of Manchester

• Value: about £595,000

Orthogonal riboswitches as tools for controlling gene expression in bacteria

• Award winner: Martin Warren

• Institution: University of Kent

• Value: about £507,000

Enzymes as traps in the elucidation of complex biochemical pathways

National Centre for the Replacement, Refinement and Reduction of Animals in Research - NC3Rs

Funding for PhD studentships

• Award winner: Colin Brown

• Institution: Newcastle University

• Value: £120,000

Development of in vitro human and rat proximal tubule cell models as a platform for drug transporter and drug-drug interaction studies

• Award winner: Alexander Easton

• Institution: Durham University

• Value: £120,000

Spontaneous recognition tasks and the 3Rs

• Award winner: Fionnuala Lundy

• Institution: Queen's University Belfast

• Value: £90,000

An in vitro model for pain and neurogenic inflammation in the oro-facial region and upper airways

• Award winner: Mark Lythgoe

• Institution: University College London

• Value: £120,000

Non-invasive in vivo imaging to investigate gene function within the brain: a new method for mouse phenotyping reducing animal use

• Award winner: Melanie Newport

• Institution: Brighton and Sussex Medical School

• Value: £90,000

Neonatal BCG vaccination: screening for genetic factors that influence host-pathogen interactions and reducing and replacing the requirement for animal infection models in immune mechanism discovery

IN DETAIL

• Award winner: Chris Haley

• Institution: Medical Research Council Human Genetics Unit

• Value: £553,000

A toolbox for the promotion of healthy ageing: phenotypic prediction from genes and environment

This project aims to develop accurate mathematical and statistical models that, by combining genetic and environmental information, will help to optimise health throughout life in both humans and animals. Together, the genes an animal inherits from its parents and the environment it experiences throughout life interact to determine health into old age. Because genetic information can be measured early in life, there is the potential to predict the specific environments that would optimise each individual's future health. The team will develop mathematical methods that make the best use of available genomic information and combine it with environmental data and across multiple traits. The project will use several approaches and compare their ability to accurately predict performance and how they may be extended to account for data from many traits and environments.