NATIONAL CENTRE FOR THE REPLACEMENT, REFINEMENT AND REDUCTION OF ANIMALS IN RESEARCH
The NC3Rs has funded 13 grants, worth a total of £4.5 million, at UK establishments. The research will advance knowledge and application for the replacement, refinement and reduction of animal experiments.
Award winner: Qasim Aziz
Institution: Queen Mary, University of London
Refinement of animal studies on emesis by defining human biomarkers of nausea
Award winner: Michael Emerson
Institution: Imperial College London
Reducing and replacing mouse use to model the human platelet response in vivo
Award winners: Berthold Gottgens and Aileen Smith
Institution: University of Cambridge
Transgenic embryonic stem-cell differentiation systems to replace transgenic-mouse analysis of tissue-specific regulatory elements
Award winners: Majid Hafezparast and Timothy Chevassut
Institution: University of Sussex
Development of induced pluripotent stem cells from mutant-mouse models to reduce animal use
Award winners: Susan Jobling, Edwin Routledge, Catherine Jones and Leslie Noble
Institutions: Brunel University and the University of Aberdeen
Of molluscs and men: the snail assay as an alternative to the Hershberger male rodent for the detection of androgens and anti-androgens
Award winners: Mark Lewis, Linda Greensmith and Vivek Mudera
Institutions: University of Bedfordshire and University College London
Engineering fully functional integrated skeletal muscle
Award winner: Ian Mackenzie
Institution: Barts and The London School of Medicine and Dentistry
Development of in vitro methods for assaying cancer stem-cell responses to therapeutic challenge
Award winners: Kevin Moffat and Bruno Frenguelli
Institution: University of Warwick
Drosophila as a model for Alzheimer's disease
Award winners: Hugh Perry and Tracey Newman
Institution: University of Southampton
A compartmentalised chamber for the in vitro study and manipulation of axon degeneration
Award winners: Johnny Roughan and Paul Flecknell
Institution: Newcastle University
Assessing the welfare of mice used in cancer research
Award winner: Vasanta Subramanian
Institution: University of Bath
iPS cells from amyotrophic lateral sclerosis patients - towards replacing animal models for ALS
Award winners: Susan Watson, Richard Argent, Anna Grabowska, Rajendra Kumari and Snjezana Stolnik-Trenkic
Institution: University of Nottingham
The human tumour micro-environment modelled in in vitro biomatrices and applied to cancer and drug discovery
Award winners: Robin S.B. Williams and Matthew Walker
Institutions: Royal Holloway, University of London and University College London
Replacing, refining and reducing animal usage in epilepsy research using a non-sentient model
IN DETAIL
ARTS AND HUMANITIES RESEARCH COUNCIL
Award winners: Joss Hands and Jussi Parikka
Institution: Anglia Ruskin University
Value £36,542
Anglia Research Centre in Digital Culture (ARC Digital)
Focusing on recent trends in global digital communications such as Facebook and Twitter, this new research centre will provide an online resource examining network politics and culture.
The two-year project, Exploring New Configurations in Network Politics, will analyse how the faster flow of communication has led to shifts in power and how this has altered political expectations - such as in Iran, where Twitter is being used to co-ordinate demonstrations.
Dr Hands and Dr Parikka will employ an expert advisory panel to contribute to the website's design, participate in discussions and encourage the involvement of other relevant parties.