WELLCOME TRUST
Investigator Awards
Investigators will receive sums ranging from £500,000 over three years to more than £3 million over seven years.
• Award winner: Finn Werner
• Institution: University College London
An integrated study of RNAP transcription
• Award winner: Steven W. Kennerley
• Institution: University College London
Neuronal mechanisms underlying value-based decision-making and action selection
MARIE CURIE CANCER CARE RESEARCH PROGRAMME
• Award winner: Jane Seymour
• Institution: University of Nottingham
• Value: £163,760
Understanding the role of nurses in decisions to use anticipatory prescriptions to manage symptoms and distress in the last days of life: a prospective community-based study using mixed methods
• Award winner: Debra Howell
• Institution: University of York
• Value: £269,728
Exploration of factors associated with place of care and death in patients with haematological malignancies
• Award winners: Maureen Coombs and Alison Richardson
• Institution: University of Southampton
• Value: £166,825
An investigation about transferring patients in critical care home to die: experiences, attitudes, population characteristics and practice
ACTION MEDICAL RESEARCH
• Award winner: John Marshall
• Institution: University College London
• Value: £124,840
Blindness: treating childhood cataracts
• Award winner: Richard Apps
• Institution: University of Bristol
• Value: £98,120
Brain tumour removal: minimising brain damage
• Award winner: Marianne Thoresen
• Institution: University of Bristol
• Value: £125,341
Birth asphyxia: preventing brain damage
• Award winner: Fiona Denison
• Institution: University of Edinburgh
• Value: £96,450
Pregnancy complications: using new imaging techniques to predict problems
• Award winner: Andres Lopez Bernal
• Institution: University of Bristol
• Value: £195,773
Preterm labour: studying the actions of oxytocin
• Award winner: Lucy Raymond
• Institution: University of Cambridge
• Value: £165,529
Stillbirth: investigating the causes
IN DETAIL
• Award winner: Rose Zamoyska
• Institution: University of Edinburgh
Mechanisms that regulate T-cell responses and their failure in autoimmunity
Immune responses are balanced through cross-talk between tyrosine kinases and phosphatases immediately downstream of T-cell receptors. Changes in expression and point mutations in these enzymes have been linked to autoimmunity. This project will explore how these mutations perturb homeostasis and lead to a failure of regulation, and at what point such perturbations tip into immunopathology and autoimmunity. A combined approach will be used, involving: modelling T-cell function and regulation in vitro and in vivo; mass spectrometry to identify global changes in the cell associated with disregulated T-cell activity; and analysis of the role of mRNA translational regulation as a control point in lymphocyte homeostasis.