Hot papers in pharmacology and toxicology

	%3Cb%3EPaper%3C/b%3E%3Cbr /%3EAuthor(s), Journal	Citations
1	Toxic Potential of Materials at the Nanolevel by Nel, A., Xia, T., Madler, L. and Li, N. Science 311 (5761): 622-6, 3 February 2006	112
2	Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer by Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M. and Mazur, M. Chemico-Biological Interactions 160 (1): 1-40 10 March 2006	110
3	Epigenetic Therapy of Cancer: Past, Present and Future Yoo, C. B. and Jones, P. A. Nature Reviews Drug Discovery 5 (1): 37-50 January 2006	87
4	Targeting Multidrug Resistance in Cancer Szakacs, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C. and Gottesman, M. M. Nature Reviews Drug Discovery 5 (3): 219-234 March 2006	76
5	Therapeutic Potential of Resveratrol: The In Vivo Evidence Baur, J. A. and Sinclair, D. A. Nature Reviews Drug Discovery 5 (6): 493-506 June 2006	68

The data above were extracted from Thomson Scientific’s Essential Science Indicators database. This database, currently covering the period January 1997 to October 2007, surveys only journal articles (original research reports and review articles) indexed by Thomson Scientific. Articles are assigned to a category based on the journals in which they were published and Thomson Scientific¹s journal-to-category field definition scheme. Both articles tabulated and citation counts to those articles are for the period indicated. Hot Papers are limited to those articles published in the last two years. A paper is selected as a hot paper if it meets a citation frequency threshold determined for its field and bi-monthly group. Citation frequency distributions are compiled for each field and cohort. Thresholds are set by finding the closest citation count that would select the top fraction of papers in each field and period. The fraction is set to retrieve about 0.1% of papers. For more information on Thomson Scientific¹s Essential Science Indicators, see http://scientific.thomson.com/products/esi.