Grant winners

MEDICAL RESEARCH COUNCIL

The Wellcome Trust

The first recipients will each receive a grant of between £1 million and £3 million, with the total allocation worth £56 million. The awards are intended to assist researchers addressing key questions about health and disease. A further nine recipients of the grant were listed in last week's Times Higher Education.

Investigator awards

• Award winner: Adrian Hill

• Institution: University of Oxford

T-cell inducing vaccines

• Award winner: Fiona Powrie

• Institution: University of Oxford

Immune pathways in the intestine in health and disease

• Award winner: David W. Holden

• Institution: Imperial College London

Intracellular biology of salmonella and streptococcus

• Award winner: Sara Rankin

• Institution: Imperial College London

Pharmacological mobilisation of progenitor cells for tissue regeneration

• Award winner: Stephen O'Rahilly

• Institution: University of Cambridge

Insulin resistance: Lessons from extreme phenotypes

• Award winner: Javier Caceres

• Institution: Medical Research Council Human Genetics Unit, Edinburgh

RNA-binding proteins in health and disease

• Award winner: V. Krishna Chatterjee

• Institution: University of Cambridge

Disorders of nuclear hormone synthesis and action: genetics and pathophysiology

• Award winner: Patrik Rorsman

• Institution: University of Oxford

Metabolic and hormonal regulation of pancreatic hormone secretion

• Award winner: Christopher Thompson

• Institution: University of Manchester

Generating order from chaos: Understanding how heterogeneity, stochastic differentiation and cell sorting can result in robust developmental patterning

• Award winner: Christiana Ruhrberg

• Institution: University College London

Defining signalling pathways that control neurovascular interactions in the brain and retina

• Award winner: Wolf Reik

• Institution: The Babraham Institute, Cambridge

Epigenetic reprogramming in mammalian development

• Award winner: Jan Lowe

• Institution: Medical Research Council Laboratory of Molecular Biology, Cambridge

Molecular architecture of the bacterial actin cytoskeleton

• Award winner: Dale Wigley

• Institution: Institute of Cancer Research

Understanding the structure and mechanism of macromolecular machines that regulate chromatin dynamics

• Award winner: Anne Ferguson-Smith

• Institution: University of Cambridge

Genomic imprinting and the epigenetic control of genome function

• Award winner: Laurence H. Pearl

• Institution: University of Sussex

Mechanisms of client protein activation and regulation by the Hsp90 molecular chaperone system

• Award winner: Pedro Hallal

• Institution: Federal University of Pelotas, Brazil

A life-course approach for understanding levels, trends, determinants and consequences of physical activity, and to inform interventions and policy for global action

European Research Council

• Award winner: James J. Heckman

• Institution: University College Dublin

• Value: €2.51 million (£2,175,350)

DEVHEALTH: Understanding health across the life course - an integrated developmental approach

IN DETAIL

• Award winners: Chris Dowson and Tim Walsh

• Institutions: University of Warwick and Cardiff University

• Value: £1,000,000 each

Canada-UK partnership on antibiotic resistance

The two teams of scientists will combine their research strengths in an effort to advance the approach to antibiotic resistance from biomedical research to clinical practice. One of the project's aims is to understand how bacteria build key components in their cell walls. The researchers intend to use resulting discoveries to develop new antimicrobials and identify new antimicrobial targets. Other project work will address the increase in resistance to key antibiotics used to fight hospital-acquired infections in a bid to create more effective inhibitors.