Hot papers in clinical medicine

	Paper Author(s), Journal	Citations
1	Cancer Statistics, 2007 A.%u2009Jemal, R.%u2009Siegel, E.%u2009Wade et al. Cancer Journal for Clinicians, 57(1): 43-66, January-February 2007	1,499
2	Effect of Rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes S.%u2009E. Nissen and K. Wolski New England Journal of Medicine, 356(24): 2457-2471, 14 June 2007	428
3	Sunitinib versus interferon alpha in metastatic renal cell carcinoma R.%u2009J. Motzer, T.%u2009E. Hutson, P. Tomczak et al. New England Journal of Medicine, 356(2): 115-124, 11 January 2007	396
4	Sorafenib in advanced clean cell renal cell carcinoma B. Escudier, T. Eisen, W.%u2009M. Stadler et al. (Target Study Group) New England Journal of Medicine, 356(2): 125-134, 11 January 2007	384
5	The consensus coding sequences of human breast and colorectal cancers T. Sjoblom, S. Jones, L.%u2009D. Wood et al.Science, 314(5797): 268-4, 13 October 2006	353
6	A genome-wide association study identifies novel risk loci for type-2 diabetes R.%u2009Sladek, G.%u2009Rocheleau, J.%u2009Rung et al.Nature, 445(7130): 881-885, 22 February 2007	323
7	Effect of Rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomized controlled trial H.%u2009C. Gerstein, S. Yusuf, R.%u2009R. Holman et al.The Lancet, 368(9541): 1096-1105, 23 September 2006	319
8	Ranibizumab for neovascular age-related macular degeneration P.%u2009J. Rosenfeld, D.%u2009M. Brown, J.%u2009S. Heier et al. (Marina Study Group) New England Journal of Medicine, 355(14): 1419-1431, 5 October 2006	290
9	A genome-wide association study of type-2 diabetes in Finns detects susceptibility variants L.%u2009J. Scott, K.%u2009L. Mohlke, L.%u2009L Bonnycastle et al.Science, 316(5829): 1341-1345, 1 June 2007	267
10	Replication of genome-wide association signals in UK samples reveals risk loci for type-2 diabetes E. Zeggini, M.%u2009N. Weedon, C.%u2009M. Lindgren et al. (WTCCC) Science, 316(5829): 1336-1341, 1 June 2007	253

The data above were extracted from the Essential Science Indicators database of Thomson Reuters. This database, currently covering the period January 1998 through October 2008, surveys only journal articles (original research reports and review articles) indexed by Thomson Reuters. Articles are assigned to a category based on the journals in which they were published and Thomson Reuters’ journal-to-category field-definition scheme. Hot papers are limited to those articles published in the past two years. A paper is selected as a hot paper if it meets a citation frequency threshold determined for its field and bimonthly group. Citation frequency distributions are compiled for each field and cohort. Thresholds are set by finding the closest citation count that would select the top fraction of papers in each field and period. The fraction is set to retrieve about 0.1 per cent of papers. For more information on Thomson Reuters’ Essential Science Indicators, see http://scientific. thomsonreuters.com/products/esi.